Eugene R. Kantner, 40, was traveling the wrong way on northbound U.S. Route 301 (Crain Highway) near Fairgrounds Road in La Plata, Charles County.
The accident occurred just after 1:30 a.m. when Kantner's 1993 Isuzu Trooper collided head-on with a 2007 Toyota Corolla.
The driver of the Corolla, Randy Jerve Datcher, 34, attempted unsuccessfully to avoid the crash. As he swerved into an adjacent lane, he side-swiped a 2010 Peterbilt tractor-trailer that was traveling next to him.
Kantner, a resident of Hazle Township, Pa., was taken to Civista Medical Center, where he was pronounced dead.
Datcher and his passenger, 32-year-old Shannelle Angela Marshall, were taken to Baltimore's Cowley Shock Trauma Center with non life-threatening injuries.
The 40-year-old truck driver, Roosevelt Raines, Jr., was uninjured.
Maryland State Police are still investigating the accident.
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